Off the cuff, some quick thoughts....
Decoupling capacitors must be as close to the RP2350 as possible and wired one per power pin on the chip. That advice goes for all other power pins on other parts too. Oscillator must be as close as possible to the chip and take caution with the grounding of the caps. Use an array of vias instead of one large plated hole under the RP2350. Trace clearance looks somewhat tight, suggest increasing it and using smaller passives to give you more flexibility. I didn't really look at the rest of the design - switching regulator in the corner looks a little odd, especially inductor - or validate the schematic.
My advice: consider using a pico module for v1 as that will eliminate much of the sensitive critical design work. But if you want to do the laid-down RP2350, I would recommend looking at some tested open source designs and borrowing as much as possible of the layout. Also read the design guide provided by Raspberry PI and take it as gospel, they provide a lot of excellent advice in there.