One of the tricky bits to watch out for is if you're booting a Plus from a Zip disk with version 4.2 of the boot driver on it, but then stick that disk into your G3 (or whatever) which has a later version of the driver loaded, it will automatically over-write the 4.2 driver on the disk with whatever driver it is using, rendering the disk unbootable on the Plus until you reinstall the 4.2 driver on the disk. The disks have a driver written in the boot area on the disks which is separate from the extension driver that gets loaded. Iomega apparently assumed you would always want the latest version of the driver on your disks.
Just FYI