Syquest was an entire company. I've heard varying reports on the reliability of their stuff, a lot of it is just that "hard platters in a plastic case you insert into a drive with heads in it" (same as Jaz) is kind of a really bad idea. IBM gave up on it in the 1960s or 70s.
I have an EZ-135 and I have had good luck with it in terms of media reliability, but I can immediately tell what the biggest problem is going to be. I like having it around, but I only have like 3-4 cartridges and one drive, so I use a serial cable and ethernet to transfer files between my old Macs instead.
I don't know if this got shown here, but I know that USB ones will work in Mac OS X 10.13.x. You won't be able to write to HFS with that version of Mac OS, but you would be able to use the drive.
10.4 or 10.5 would probably be a good mid-point in terms of being a good OS for going on web sites that v4/v5 browsers can't load (like mac garden) and also for writing to external media that is HFS formatted.