I've seen some frankenstein drives out there ... much of the parts are interchangeable in the 100 series so I've seen real pluses living inside a normal 100 case and vice versa, so probably pointing out the obvious but make sure the rear panel has a scsi ID selector otherwise it doesn't support scsi.
That said, I use a plus with my macs. I'm using a DB25 scsi cable (Male to Female) and using the female end on the auto detect port of the zip plus. Works great. Note that it will work without the driver, but without the driver, disks will not auto mount or auto eject. You will need to use scsi probe or similar tool to mount the disks after inserting them.