What software do you use? Do you have a disk image with a typical setup of yours? I do have a few synthesizers and can give your setup a try. There's still the possibility that some software won't work as intended, since I still may have parts of the hardware wrong or incomplete.
Do you use Cubase? That's the only MIDI software for Mac that I have tested, yet. What else might need testing?
One interesting part is that Cubase on the Atari came with a dongle while the Mac version doesn't seem to have had one, did it? For the Atari, a bunch of unreliable cracks existed. But in the meantime the dongles have been analyzed and are simply implemented in the FPGA as well. So this now works reliably, and I do know that the MiST has been used as an Atari on stage. I'd love to see the NanoMac to be used that way as well.
However, you'll need some hardware. There was one person on Ebay who seemed to be selling the hardware, although that particular version had a bug in the MIDI IN circuit, as I found out once a musician complained.
The software I use is called "M" by Intelligent Music. It's an "intelligent" algorithmic sequencer with the intention to blur the line between composition and improvisation. I've been using it for many years now, including on tour using MiST and MiSTer. The best and original version is for Mac, though it's been ported to Amiga and Atari ST (There's even a PC port for DOS, though after lots of searches I've never been able to find it). The Mac version is more developed and extensive, I ran this on a Powerbook Duo 230 at first, and now my main system for shows is a PPC port of "M" running on an ibook G3. I can definitely prepare a disk image with some prepared session files, which should work upon opening, without setting anything up. The software is intended as an interactive MIDI instrument, so it's a different approach from Cubase, which is more like a recording system. "M" can be controlled via two MIDI control changes, that I can pre-define and save in the prepared file, as well as with real-time keyboard input, making it a bit like an arpeggiator. This way it should work instantly to test MIDI input as wel as output without setting anything up. It can also output MIDI clock, and I'd love to make some measurements to test the jitter amount compared to original hardware. I know the jitter of the Atari ST is actually quite different when comparing FPGA to real hardware, where the MiSTer is actually way tighter than the orignal ST. The ST is already pretty tight, but I found it interesting to hear there's still a difference.
I'd say if Cubase works, "M" should also work, but for the ST core this is strangely not the case. the ST port of "M" is actually the only software that doesn't seem to work at all on FPGA, while everything else I've tried does work really well, strangely (And I've tested over 100 MIDI tools on that platform).
And yes I've tested the Cubase dongle emulator as well on FPGA and works great! I love using the IPS in Cubase, a brilliant and super unique approach to MIDI, where pre-recorded phrases can be repurposed based on your keyboard input, blurring the line between what's live and what's recorded.
I bought an empty Mac Plus case, and an LCD made for the Plus, and I've been planning to turn this into an FPGA mac for shows without vulnerable parts, though without MIDI on the FPGA it was an unfinished project, so now I can finally finish it. Considering the size of the NanoMac and the amount of empty space in the case, it may even be possible to fit multiple Nanomacs inside to distrubute compute over multiple MIDI tools (like Opcode's MAX for example) or to set up a backup NanoMac in case of an issue during a performance without bringing a second machine ...