Finally did my testing. First off, this device does support 8GB CF cards. My Transend 8GB 133X CF card was recognized without a problem. I'll also add that it supports very small CF cards too as a Canon branded 8MB CF card worked without a problem.
Connection to desktop machines was with a Cables-to-Go 2.5" to 3.5" SCSI adapter. What I did have a problem with is with host controllers. My 486's Adaptec AHA-2740W EISA card (40MB/sec WideSCSI with 50/68pin plugs) wouldn't see it at all, but I have had problems with that card seeing devices in the past. My PCI AHA-2920C card (10MB/sec fast SCSI) worked fine with it. Anyway this device is.... slow.
Here is the native speed of the device running off of a Promise UltraTX2 ATA100 card as a baseline:
These speeds check out with Transend's data sheet.
For comparison, here is the card running off of the onboard IDE ports, likely using PIO transfer mode (DMA disabled). This is very close to what I get running this CF card on an ISA bus controller:
The Adcom off of the Adaptec SCSI card:
OUCH. Performance in anything remotely modern with this device is going to be lousy. Good thing the only 2.5" SCSI devices out there are old and slow anyway. Its a good choice for old computers like Powerbooks though. Whats sad is the SCSI controller on the Adcom adapter supports 20MB/sec transfers, so the bottleneck is likely the firmware, ATA interface, or CPU. I would love to get a hold of one of the ACARD adapters or the Power Monster and see how they compare to this. I wouldn't be surprised if they are much faster.