A few other thoughts. As is commonly known, the oscillator on the IIsi can be replaced and the machine clocked up to at least 25 MHz. Some have taken it to 27 or 28 MHz. A few MHz may not sound like much, but at those overall speeds, each MHz is a substantial percentage of the total.
The NuBus adapter could probably support multiple slots, but it would require major modifications. Once you have the NuBus circuitry at all, most of the work is done. The modifications would be to actually get the additional connectors wired to the board, and to wire the slot ID pins properly, adn finally to identify some additional unique interrupt lines to connect the slots' interrupt to--one interrupt per slot. I imagine the chipset has the interrupts available on some of the pins, since the chips are probably the same or very similar to those used in the IIci.
It would be interesting to try wiring larger memory capacity into the built-in 1 MB bank of memory. Again, given the simiilarities to the IIci, it should be able to take 64 MB in that bank.
But then, once you've gone to all the trouble above, you'd just have a IIci, so really, I guess it's kind of silly.