You're best off using iWeb or a modern version of FrontPage with Windows. iWeb is especially easy to use but you're somewhat limited in terms of templates. FrontPage gives you more flexibility but it's a bit harder to use (mostly because of its power).
It all depends upon what you are trying to accomplish. If you're looking for something that uses a recent HTML specification, CSS, and EMCAScript then using old software is going to create more problems than it is worth. From a design perspective, if you are trying to create a website with a reasonably sophisticated layout then using old software is going to create more problems than it is worth.
On the other hand, if you're goal is to create an attractive page that conveys information then a lot of that old software will be just fine thank-you. Of course, that old software will handle simple pages that structure content into different sections using either visual cues (e.g. headings) or separate pages. It will also allow you to add figures that illustrate what you're talking about. Graphical design elements can be handled too, to the point where you could create a reasonable fascimile of the 68k MLA forums. Of course some stuff would be impractical, such as the rounded corners and gradients that grace this website. But that is by no means necessary for conveying information.
While I can't claim to have used Frontpage, Claris HomePage is a reasonable design medium even though it lacks a lot of the eye candy we take for granted today.