Sorry, I may repeat information that has already been discussed, but hopefully it's useful to someone...
What worked for me, with a SCSI2SD 5.1 (
https://amigakit.amiga.store/product_info.php?products_id=1264)
I didn't change any settings on the General Settings page
I chose to "Load defaults" onto the card, after updating the firmware.
I then booted from my FloppyEmu, using the HD20.dsk image provided by BMOW (this is a System 6.0.8 install with Lido and other useful utilities) - Lido was the only thing that would see my card and let me format it.
Even the patched version of HD SC Setup could not see the card, with default settings or with disguising it as a SEAGATE.
So once Lido had formatted it, I was able to mount my drive, I dragged over a copy of System 6.0.8 from the FloppyEmu image I was using, and restarted the computer to boot from that. I have never seen a Mac boot so fast, it was pretty much near-instant, must have been 2-3 seconds max.
I used a 16GB Sandisk card but decided to only set up the first 2GB, so the Mac only sees 2GB. I could change this in future if I needed more but 2GB for System 6/7 is PLENTY!
Thanks for everyone for putting so much time and effort into making guides and discussing SCSI2SD set up. I tried it many many years ago and failed, but this time it seemed pretty easy, as soon as I tried Lido.